Evaluation of In Vitro Antiprotease Activity of Selected Traditional Medicinal Herbs in Dentistry and Its In Silico PASS Prediction

Table 2

In vitro anti-inflammatory activity of aqueous extracts of selected medicinal plants by protease inhibition method.

Plant name	Conc (μg mL^-1)	OD	% inhibition	IC50
Blank	—	2.138	—	—
Standard (diclofenac sodium)	100	1.221	42.89	93.00
	200	0.905	57.67
	400	0.851	60.19
	800	0.768	64.07
	1000	0.704	67.07
Azadirachta indica Linn	100	1.211	43.35	96.19
	200	0.938	56.12
	400	0.819	61.69
	800	0.774	63.79
	1000	0.689	67.77
Piper nigrum Linn	100	1.481	30.72	371.20
	200	0.969	54.67
	400	0.912	57.34
	800	0.827	61.31
	1000	0.811	62.06
Terminalia chebula	100	1.869	12.58	639.48
	200	1.752	18.05
	400	0.969	54.67
	800	0.861	59.72
	1000	0.715	66.55
Camellia sinensis Linn	100	1.121	47.56	188.50
	200	1.010	52.75
	400	0.990	53.69
	800	0.877	58.98
	1000	0.645	69.83

Values represented in the results are of three replicates; linear regression analysis was used to calculate IC50 value).