KIF22 Promotes Development of Pancreatic Cancer by Regulating the MEK/ERK/P21 Signaling Axis

Figure 3

KIF22 plays a vital role in the regulation of the pancreatic cancer cell cycle. (a) KIF22 is highly enriched in the cell cycle pathway in pancreatic cancer analyzed by Gene Set Enrichment Analysis (GSEA). (b, c) The level of KIF22 expression was found to be positively correlated with the positive ratio of Ki67 cells. (d) Silencing KIF22 causes the significant upregulation of G1 and S phase populations in PANC-1 and MIA-PaCa-2, as well as downregulation of G2 and M phase populations.

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