Determination of Risk Factors Associated with the Failure of 12 Weeks of Direct-Acting Antiviral Therapy in Patients with Hepatitis C: A Prospective Study
Table 2
Multiple variable logistic regression models based on the test dataset.
Model
Independent variable
Slope
SE
OR (97.5%CI)
Model 1
Intercept
-55.38
33.69
0.101
0.01 (0.01, 0.01)
Number of comorbidities
-2.06
1.56
0.186
0.13 (0.01, 1.5)
Cirrhosis
10.59
4.75
0.026
39344.68 (37.88, 4887573)
HBV coinfection
8.01
5.88
0.174
3004.94 (0.49, 1197994)
Genotype 2
8.18
4.39
0.063
3564.85 (6.24, 4097476)
Genotype 3
-2.99
2.41
0.214
0.06 (0.01, 3.83)
Genotype 6
-2.17
1.88
0.249
0.12 (0.01, 3.52)
Medication (SOF.VEL)
6.06
2.86
0.034
428.1 (5.32, 717602.2)
Baseline AST
0.14
0.08
0.057
1.15 (1.05, 1.44)
Baseline ALP
0.12
0.07
0.069
1.12 (1.03, 1.36)
Baseline creatinine
0.19
0.1
0.056
1.2 (1.05, 1.59)
Baseline GFR
0.1
0.06
0.09
1.1 (1.01, 1.29)
Baseline hemoglobin
-0.35
0.18
0.053
0.71 (0.41, 0.9)
Plt_pre
0.03
0.02
0.225
1.03 (1, 1.08)
FIB_4
3.48
1.66
0.036
32.45 (3.27, 4953.69)
Baseline viral load (log10 IU/ml)
3.03
1.58
0.056
20.52 (2.71, 3935)
RVR
22.94
24.65
0.353
91353 (250.95, 1024875)
Model 2
Intercept
-44.75
18.76
0.017
0.01 (0.01, 0.01)
Number of comorbidities
-2.22
1.4
0.111
0.11 (0.01, 1.05)
Cirrhosis
10.43
4.11
0.012
33528.71 (52.01, 1364237)
HBV coinfection
6.21
4.9
0.206
494.86 (0.21, 411352200)
Genotype 2
7.17
3.72
0.054
1296.44 (4.39,84435790)
Genotype 3
-3.06
2.14
0.153
0.05 (0.01, 2.44)
Genotype 6
-2.71
1.79
0.129
0.07 (0.01, 1.67)
Medication SOF.VEL
6.89
2.99
0.022
975.47 (9.17, 2460177)
Baseline AST
0.13
0.06
0.033
1.14 (1.05, 1.33)
Baseline ALP
0.1
0.05
0.047
1.1 (1.03, 1.24)
Baseline creatinine
0.15
0.08
0.036
1.16 (1.05, 1.41)
Baseline GFR
0.09
0.05
0.063
1.09 (1.01, 1.23)
Baseline hemoglobin
-0.31
0.14
0.024
0.74 (0.51, 0.9)
FIB_4
3.31
1.35
0.015
27.17 (3.64, 1049.77)
Baseline viral load (log10 IU/ml)
2.69
1.26
0.033
14.64 (2.41, 517.5)
RVR
21.39
9.28
0.022
1933120000 (4542.83, 7.439031E+21)
Model 3
Intercept
-30.52
11.36
0.008
0.01 (0.01, 0.01)
Cirrhosis
7.23
2.82
0.011
1372.69 (16.17, 1459831)
HBV coinfection
0.75
2.35
0.75
2.12 (0.03, 642.88)
Genotype 2
5.8
2.64
0.028
328.87 (4.3, 236966)
Genotype 3
-2.18
2.05
0.289
0.12 (0.01, 3.62)
Genotype 6
-2.3
1.63
0.157
0.11 (0.01, 1.85)
Medication SOF.VEL
4.31
2.02
0.033
73.79 (3.02, 17293.09)
Baseline AST
0.08
0.03
0.012
1.08 (1.03, 1.17)
Baseline ALP
0.04
0.03
0.052
1.05 (1.01, 1.1)
Baseline creatinine
0.1
0.05
0.033
1.1 (1.03, 1.23)
Baseline GFR
0.06
0.04
0.106
1.06 (1, 1.15)
Baseline hemoglobin
-0.18
0.08
0.019
0.84 (0.68, 0.94)
FIB_4
2.11
0.78
0.007
8.18 (2.46, 60.01)
Baseline viral load (log10 IU/ml)
1.51
0.66
0.022
4.51 (1.7, 26.08)
RVR
14.94
5.58
0.008
3058150 (791.41, 27932120000000)
Model 4
Intercept
-20.77
7.95
0.009
0.01 (0.01, 0.01)
Cirrhosis
4.9
1.87
0.009
134.18 (7.16, 16212.11)
Genotype 2
3.43
1.93
0.076
30.85 (1.38, 5070.96)
Genotype 3
-2.44
1.95
0.212
0.09 (0.01, 2.33)
Genotype 6
-2.97
1.55
0.056
0.06 (0.01, 0.76)
Medication SOF.VEL
4.03
2.17
0.063
55.74 (2.1, 14922.96)
Baseline AST
0.06
0.03
0.012
1.07 (1.03, 1.13)
Baseline ALP
0.03
0.02
0.067
1.03 (1.01, 1.08)
Baseline creatinine
0.06
0.04
0.08
1.06 (1.01, 1.15)
Baseline hemoglobin
-0.13
0.07
0.041
0.89 (0.76, 0.97)
FIB_4
1.47
0.56
0.008
4.34 (1.87, 18.26)
Baseline viral load (log10 IU/ml)
1.29
0.53
0.014
3.63 (1.56, 14.42)
RVR
12.04
4.6
0.009
169281.6 (211.77, 35097410000)
Model 5
Intercept
-16.86
6.76
0.013
0.01 (0.01, 0.01)
Cirrhosis
4.05
1.51
0.008
57.3 (4.77, 2162.94)
Genotype 2
2.79
1.62
0.085
16.26 (1.01, 819.57)
Genotype 3
-2.1
1.71
0.221
0.13 (0.01, 2.36)
Genotype 6
-2.83
1.53
0.064
0.06 (0.01, 0.83)
Medication SOF.VEL
3.13
1.68
0.062
22.73 (1.45, 1374.49)
Baseline AST
0.06
0.02
0.009
1.06 (1.02, 1.11)
Baseline ALP
0.03
0.02
0.054
1.03 (1.01, 1.08)
Baseline hemoglobin
-0.1
0.05
0.04
0.92 (0.82, 0.98)
FIB_4
1.28
0.47
0.006
3.58 (1.72, 11.6)
Baseline viral load (log10 IU/ml)
1.34
0.49
0.006
3.81 (1.73, 13.37)
RVR
9.26
3.37
0.007
10411.78 (60.84, 45946530)
Model 6
Intercept
-11.61
5.13
0.024
0.01 (0.01, 0.1)
Cirrhosis
3.74
1.3
0.004
41.71 (4.65, 893.62)
Genotype 2
2.53
1.44
0.08
12.44 (0.91, 293.43)
Genotype 3
-1.43
1.32
0.279
0.25 (0.02, 2.85)
Genotype 6
-2.94
1.48
0.048
0.06 (0.01, 0.7)
Baseline AST
0.04
0.02
0.01
1.04 (1.02, 1.08)
Baseline ALP
0.03
0.01
0.037
1.03 (1.01, 1.05)
Baseline hemoglobin
-0.07
0.04
0.027
0.94 (0.87, 0.99)
FIB_4
0.91
0.34
0.007
2.47 (1.4, 5.33)
Baseline viral load (log10 IU/ml)
1.03
0.39
0.008
2.8 (1.46, 6.9)
RVR
6.06
2.11
0.004
427.63 (15.54, 7179.67)
HBV, hepatitis B virus; HCV, hepatitis C virus; RVR, rapid virological response; LDV/SOF, ledipasvir/sofosbuvir; VEL/SOF: sofosbuvir/velpatasvir; AST: aspartate aminotransferase; ALT: alanine transaminase; FIB-4: fibrosis index based on four factors; GFR: glomerular filtration rate.
