Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways

<div>Pretreatment with rosiglitazone (RSG) prevented APAP-induced acute liver injury and reduced mortality. (a, b) Pretreatment with RSG reversed APAP-induced elevations in serum ALT (a) and AST (b). (c) Pretreatment with RSG prevented APAP-induced depletion of hepatocellular GSH. 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602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.365,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> compared to the APAP group at the same time point. (d) Rosiglitazone pretreatment reduced APAP-induced mortality.</div>

BioMed Research International

fig1

Figure 1

Figure 1: Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways 