Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways

<div>Rosiglitazone pretreatment mitigated APAP-induced hepatic pan-necrosis and apoptosis. (a) Hematoxylin and eosin staining of liver sections (magnification: 100×) showing regions of pan-necrosis. (b) Quantification of necrotic area. The necrotic areas in APAP-treated mice were significantly reduced by RSG pretreatment. (c) TUNEL staining of apoptotic hepatocytes (magnification: 100×). (d) RSG pretreatment significantly reduced the number of apoptotic (TUNEL+) hepatocytes in APAP-injected mice. 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BioMed Research International

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Figure 2

Figure 2: Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways 