Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways

<div>Pretreatment with RSG reversed APAP-induced activation of the hepatic PERK-eIF2<i>α</i>-CHOP pathway. (a) Representative immunoblots of hepatic p-PERK (upper panel) and <i>α</i>-tubulin (lower panel) as the gel loading control. (b) Densitometry of p-PERK expression showing upregulation by APAP and reversal by RSG pretreatment. (c) Representative immunoblots of hepatic p-eIF2 <i>α</i> (upper panel) and <i>α</i>-tubulin (lower panel). (d) Densitometry showing p-eIF2 <i>α</i> upregulation by APAP and reversal by RSG pretreatment. (e) Representative immunoblots of hepatic CHOP (upper panel) and <i>α</i>-tubulin (lower panel). (f) Densitometry showing CHOP upregulation by APAP and reversal by RSG pretreatment. 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BioMed Research International

fig4

Figure 4

Figure 4: Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways 