Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways

<div>Rosiglitazone pretreatment suppressed APAP-induced activation of the hepatic IRE-XBP1-JNK pathway. (a) Representative immunoblots of hepatic p-IRE (upper panel) and IRE (lower panel). (b) Densitometry of p-IRE showing upregulation by APAP and reversal by RSG pretreatment. (c) Representative immunoblots of hepatic p-JNK (upper panel) and JNK (lower panel). (d) Densitometry of p-JNK showing upregulation by APAP and reversal by RSG pretreatment. (e) Representative immunoblots of hepatic XBP1 (upper panel) and LaminA/C (lower panel) as the gel loading control. (f) Densitometry of XBP1 showing upregulation by APAP and reversal by RSF pretreatment. 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BioMed Research International

fig5

Figure 5

Figure 5: Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways 