Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways

<div>Rosiglitazone pretreatment suppressed APAP-induced activation of the hepatic ATF6 pathway. (a) Representative immunoblots of hepatic ATF6 (upper panel) and LaminA/C (lower panel). (b) Densitometry of ATF6 showing upregulation by APAP and reversal by RSG pretreatment. (c) Representative immunoblots of hepatic caspase-3 (upper panel) and <i>α</i>-tubulin (lower panel). (d) Densitometry of caspase-3 showing upregulation by APAP and reversal by RSG pretreatment. 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BioMed Research International

fig6

Figure 6

Figure 6: Rosiglitazone Protects against Acetaminophen-Induced Acute Liver Injury by Inhibiting Multiple Endoplasmic Reticulum Stress Pathways 