Integrated Brain Metabolomics and Network Pharmacology Analysis to Reveal the Improvement Effect of Bai Chan Ting on Parkinson’s Disease

Table 3

Target information of BCT treating PD in network pharmacology.

No.	Gene symbol	Uniprot ID	Protein name
1	ALDH2	P05091	Aldehyde dehydrogenase
2	LAP3	P28838	Cytosol aminopeptidase
3	P4HA1	P13674	Prolyl 4-hydroxylase subunit alpha-1
4	NOS3	P29474	Nitric oxide synthase
5	AMD1	P17707	S-adenosylmethionine decarboxylase proenzyme
6	NOS1	P29475	Nitric oxide synthase
7	GSR	P00390	Glutathione reductase
8	TP53	P04637	Cellular tumor antigen p53
9	SLC6A3	Q01959	Sodium-dependent dopamine transporter
10	LRRK2	Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2
11	BCL2L1	Q07817	Bcl-2-like protein 1
12	MAPT	P10636	Microtubule-associated protein tau
13	MAP3K5	Q99683	Mitogen-activated protein kinase kinase kinase 5
14	PSMB5	P28074	Proteasome subunit beta type-5
15	DRD1	P21728	D(1A) dopamine receptor (dopamine D1 receptor)
16	MAPK8	P45983	Mitogen-activated protein kinase 8
17	MAPK9	P45984	Mitogen-activated protein kinase 9
18	GLUL	P15104	Glutamine synthetase
19	GAPDH	P04406	Glyceraldehyde-3-phosphate dehydrogenase
20	ARG1	P05089	Arginase-1
21	IDH1	O75874	Isocitrate dehydrogenase [NADP] cytoplasmic
22	TLR4	O00206	Toll-like receptor 4
23	TNF	P01375	Tumor necrosis factor
24	AOC3	Q16853	Membrane primary amine oxidase
25	SPTLC1	O15269	Serine palmitoyltransferase 1
26	GLB1	P16278	Beta-galactosidase
27	GBA	P04062	Lysosomal acid glucosylceramidase
28	GBA2	Q9HCG7	Non-lysosomal glucosylceramidase
29	FBP1	P09467	Fructose-1
30	PLA2G1B	P04054	Phospholipase A2
31	CYP3A4	P08684	Cytochrome P450 3A4
32	HK2	P52789	Hexokinase-2
33	HSPA5	P11021	Endoplasmic reticulum chaperone BiP
34	DAO	P14920	D-amino-acid oxidase
35	GAA	P10253	Lysosomal alpha-glucosidase
36	NOX4	Q9NPH5	NADPH oxidase 4
37	MAPK10	P53779	Mitogen-activated protein kinase 10
38	CXCR2	P25025	C-X-C chemokine receptor type 2
39	ERN1	O75460	Endoplasmic reticulum-to-nucleus signaling 1
40	CASP3	P42574	Caspase-3
41	PTGS2	P35354	Prostaglandin G/H synthase 2
42	HCAR2	Q8TDS4	Hydroxycarboxylic acid receptor 2
43	TK1	P04183	Thymidine kinase
44	MAP3K7	O43318	Mitogen-activated protein kinase kinase kinase 7
45	SLC6A4	P31645	Sodium-dependent serotonin transporter
46	RAF1	P04049	RAF proto-oncogene serine/threonine-protein kinase
47	DRD4	P21917	Dopamine D4 receptor
48	GSK3A	P49840	Glycogen synthase kinase-3 alpha
49	MAPK14	Q16539	Mitogen-activated protein kinase 14
50	PRKCG	P05129	Protein kinase C gamma type
51	GRIA2	P42262	Glutamate receptor 2
52	PRKCB	P05771	Protein kinase C beta type
53	DRD5	P21918	Dopamine D5 receptor
54	GSK3B	P49841	Glycogen synthase kinase-3 beta
55	MAPK11	Q15759	Mitogen-activated protein kinase 11
56	DRD2	P14416	Dopamine D2 receptor
57	DRD3	P35462	Dopamine D3 receptor
58	PRKCA	P17252	Protein kinase C alpha type
59	PPP2CA	P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
60	AKT1	P31749	RAC-alpha serine/threonine-protein kinase
61	LYN	P07948	Tyrosine-protein kinase Lyn
62	ALOX12	P18054	Polyunsaturated fatty acid lipoxygenase ALOX12
63	CYP2C9	P11712	Cytochrome P450 2C9
64	PTGES	O14684	Prostaglandin E synthase
65	PTGS1	P23219	Prostaglandin G/H synthase 1
66	CYP2C19	P33261	Cytochrome P450 2C19
67	ALOX5	P09917	Polyunsaturated fatty acid 5-lipoxygenase
68	EPHX2	P34913	Bifunctional epoxide hydrolase 2
69	OPRD1	P41143	Delta-type opioid receptor
70	CTSD	P07339	Cathepsin D
71	MAP2K2	P36507	Dual specificity mitogen-activated protein kinase kinase 2
72	MAPK3	P27361	Mitogen-activated protein kinase 3
73	PLD2	O14939	Phospholipase D2
74	AKT3	Q9Y243	RAC-gamma serine/threonine-protein kinase
75	PIK3CA	P42336	Phosphatidylinositol 4
76	KNG1	P01042	Kininogen-1
77	MAP2K1	Q02750	Dual specificity mitogen-activated protein kinase kinase 1
78	ROCK2	O75116	Rho-associated protein kinase 2
79	PLD1	Q13393	Phospholipase D1
80	FYN	P06241	Tyrosine-protein kinase Fyn
81	ADORA1	P30542	Adenosine receptor A1
82	ROCK1	Q13464	Rho-associated protein kinase 1
83	HRAS	P01112	GTPase HRas
84	MAPK1	P28482	Mitogen-activated protein kinase 1
85	HTR2B	P41595	5-hydroxytryptamine receptor 2B
86	HTR2C	P28335	5-hydroxytryptamine receptor 2C
87	BRAF	P15056	Serine/threonine-protein kinase B-raf
88	HTR6	P50406	5-hydroxytryptamine receptor 6
89	HTR1A	P08908	5-hydroxytryptamine receptor 1A
90	HTR7	P34969	5-hydroxytryptamine receptor 7
91	CYP2D6	P10635	Cytochrome P450 2D6
92	PLA2G4A	P47712	Cytosolic phospholipase A2
93	HTR1B	P28222	5-hydroxytryptamine receptor 1B
94	HTR2A	P28223	5-hydroxytryptamine receptor 2A
95	GRM5	P41594	Metabotropic glutamate receptor 5
96	ADRBK1	P25098	Beta-adrenergic receptor kinase 1
97	GLS	O94925	Glutaminase kidney isoform
98	GRM1	Q13255	Metabotropic glutamate receptor 1
99	GRIK1	P39086	Glutamate receptor ionotropic
100	MAOA	P21397	Amine oxidase [flavin-containing] A
101	MAOB	P27338	Amine oxidase [flavin-containing] B