[Retracted] Effect of Previous Cancer History on Survival of Patients with Different Subtypes of Breast Cancer

Table 2

Impact of prior cancer history on the survival of patients with different breast cancer subtypes.

Populations	Samples	Subgroups	Model 1		Mode 2		Model 3
Total	35640		HR (95% CI)		HR (95% CI)		HR (95% CI)
	33602	No	Ref		Ref		Ref
	672	Prior female genital/endocrine system cancer history	1.27 (1.08-1.51)	0.005	1.07 (0.91-1.27)	0.412	1.38 (1.16-1.63)	<0.001
	1366	Prior other cancers history	1.81 (1.63-2.00)	<0.001	1.41 (1.27-1.56)	<0.001	1.55 (1.40-1.72)	<0.001
Triple negative	3568	No	Ref		Ref		Ref
	73	Prior female genital/endocrine system cancer history	1.31 (0.92-1.87)	0.137	1.22 (0.86-1.75)	0.267	1.70 (1.18-2.43)	0.004
	122	Prior other cancers history	1.62 (1.25-2.11)	<0.001	1.31 (1.01-1.72)	0.045	1.49 (1.14-1.96)	0.004
HER2 positive	23197	No	Ref		Ref		Ref
	500	Prior female genital/endocrine system cancer history	1.35 (1.10-1.66)	0.005	1.10 (0.89-1.36)	0.372	1.32 (1.08-1.64)	0.008
	1057	Prior other cancers history	1.90 (1.67-2.15)	<0.001	1.45 (1.28-1.65)	<0.001	1.48 (1.31-1.68)	<0.001
Luminal A	2318	No	Ref		Ref		Ref
	35	Prior female genital/endocrine system cancer history	0.81 (0.36-1.81)	0.603	0.65 (0.29-1.45)	0.294	0.88 (0.39-1.99)	0.758
	53	Prior other cancers history	2.00 (1.30-3.06)	0.002	1.47 (0.96-2.26)	0.081	1.64 (1.06-2.55)	0.027
Luminal B	4429	No	Ref		Ref		Ref
	64	Prior female genital/endocrine system cancer history	1.22 (0.69-2.16)	0.497	1.04 (0.59-1.84)	0.889	1.49 (0.84-2.67)	0.175
	134	Prior other cancers history	2.50 (1.85-3.38)	<0.001	1.85 (1.37-2.51)	<0.001	2.50 (1.83-3.43)	<0.001
Age: 18-40 years	2734	No	Ref		—		Ref
	13	Prior female genital/endocrine system cancer history	—		—	—	—	—
	31	Prior other cancers history	0.91 (0.29-2.84)	0.871	—	—	2.00 (0.62-6.41)	0.245
Age: 40-44 years	19590	No	Ref				Ref
	299	Prior female genital/endocrine system cancer history	1.42 (1.08-1.87)	0.012	—	—	1.84 (1.40-2.43)	<0.001
	433	Prior other cancers history	1.66 (1.35-2.05)	<0.001	—	—	2.19 (1.77-2.72)	<0.001
Age: ≥65 years	11278	No	Ref		—		Ref
	360	Prior female genital/endocrine system cancer history	0.95 (0.77-1.17)	0.611	—	—	1.18 (0.95-1.46)	0.132
	902	Prior other cancers history	1.35 (1.19-1.51)	<0.001	—	—	1.39 (1.23-1.57)	<0.001
Race: blacks	4251	No	Ref		Ref		Ref
	54	Prior female genital/endocrine system cancer history	0.97 (0.56-1.68)	0.919	0.87 (0.50-1.51)	0.624	1.28 (0.74-2.23)	0.381
	137	Prior other cancers history	1.45 (1.08-1.94)	0.014	1.25 (0.93-1.68)	0.149	1.41 (1.04-1.92)	0.027
Race: Hispanics	4195	No	Ref		Ref		Ref
	73	Prior female genital/endocrine system cancer history	1.38 (0.78-2.45)	0.268	1.25 (0.71-2.22)	0.440	1.91 (1.07-3.41)	0.030
	86	Prior other cancers history	2.29 (1.55-3.39)	<0.001	2.02 (1.36-3.00)	<0.001	2.12 (1.41-3.18)	<0.001
Race: others	3434	No	Ref		Ref		Ref
	55	Prior female genital/endocrine system cancer history	1.47 (0.79-2.75)	0.229	1.35 (0.72-2.53)	0.347	1.98 (1.04-3.75)	0.037
	61	Prior other cancers history	1.71 (0.99-2.97)	0.057	1.41 (0.81-2.45)	0.229	1.55 (0.88-2.72)	0.130
Race: whites	21722	No	Ref		Ref		Ref
	490	Prior female genital/endocrine system cancer history	1.33 (1.10-1.62)	0.004	1.09 (0.90-1.32)	0.393	1.32 (1.08-1.60)	0.006
	1082	Prior other cancers history	1.84 (1.64-2.06)	<0.001	1.39 (1.23-1.56)	<0.001	1.54 (1.36-1.73)	<0.001

Note: model 1, univariate analysis model; model 2, age-adjusted model; model 3, multivariate analysis model that adjusted for age, race, marital status, grade, ER (or not), PR (or not), T stage, N stage, chemotherapy, radiation, surgery, and regional nodes positive; model 3 did not adjust for ER and PR when performing an analysis on populations with triple negative, HER2 positive, Luminal A, and Luminal B; HR: hazard ratio; 95% CI: 95% confidence interval.