Research Article

Anti-CD44 and EGFR Dual-Targeted Solid Lipid Nanoparticles for Delivery of Doxorubicin to Triple-Negative Breast Cancer Cell Line: Preparation, Statistical Optimization, and In Vitro Characterization

Figure 8

Evaluation of the cytotoxicity of the different formulations after 48 h incubation with MDA-MB-468 cell line. (a) Cytotoxicity comparison between DOX, SLNs/DOX, and DOX-SLNs-Dexa. (b) Cytotoxicity comparison between SLNs/DOX/Dexa with SLNs/DOX/Dexa/EGFR, SLN/Dox/Dexa/CD44, and SLNs/DOX/Dexa/CD44/EGFR. SLNs/DOX/Dexa/CD44/EGFR are substantially more effective in reducing the cell line viability (, , , and ).
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