hnRNPC Promotes Malignancy in Pancreatic Cancer through Stabilization of IQGAP3

Figure 1

hnRNPC is highly expressed in pancreatic cancer tumor tissues. (a) hnRNPC expression levels in pancreatic adenocarcinoma (PAAD) tissues in TCGA database. (b) Relative mRNA expression levels of hnRNPC in 14 paired PDAC tissues and adjacent noncancerous pancreatic tissues, as determined by RT-PCR. (c) Relative mRNA expression of hnRNPC in PDAC tissues was stratified by clinical stage, TNM stage I-II (), TNM stage III-IV (). (d, e) Protein expression levels of hnRNPC in patients with PDAC were detected by western blot analysis of the paired PDAC and adjacent noncancerous pancreatic tissues (N: adjacent noncancerous pancreatic tissues; T: tumor tissues, ). (f) Overall survival evaluated between pancreatic cancer patients with high and low expression of hnRNPC of pancreatic cancer patients from TCGA. (g) IHC staining of 3 pairs of human PDAC tumor tissues (tumor) and adjacent noncancerous pancreatic tissues (nontumor) for hnRNPC expression. Data were analyzed by a paired Student’s -test. Scale bars: 50 μm. .

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