hnRNPC Promotes Malignancy in Pancreatic Cancer through Stabilization of IQGAP3

Figure 4

hnRNPC upregulated IQGAP3 expression and promoted tumor growth in a mouse xenograft model. (a–c) BxPC-3 cells with hnRNPC stable knockdown and PANC-1 cells with stable hnRNPC overexpression were injected subcutaneously into nude mice ( cells per mouse, five mice per group). Representative images of tumors are presented; tumor growth curves (b) and tumor weights (c) are shown. (d) hnRNPC and IQGAP3 expression in four groups was detected by IHC. H&E staining and Ki-67 immunohistochemical staining of tumor sections. 400x magnification. All data shown are the of three independent experiments. Statistical significance was calculated using Student’s -test or one-way ANOVA. , , .

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