hnRNPC Promotes Malignancy in Pancreatic Cancer through Stabilization of IQGAP3

<div>hnRNPC promoted PDAC cell EMT through IQGAP3. (a, b) Western blot analysis of EMT marker proteins (E-cadherin, N-cadherin, and vimentin) and IQGAP3 in BxPC-3 and PANC-1 cells transfected with the respective shRNA or overexpression plasmids and normalized by GAPDH. (c, d) Representative immunofluorescence images of EMT protein (E-cadherin, N-cadherin, and vimentin) expression levels in BxPC-3 and PANC-1 cells transfected with the respective shRNA or overexpression plasmids, <span class="nowrap"><svg height="12.7373pt" id="M71" style="vertical-align:-3.429399pt" version="1.1" viewbox="-0.0498162 -9.3079 64.8 12.7373" width="64.8pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M152 404V712C115 698 54 683 7 677V654C71 648 73 642 73 579V24C128 -2 179 -12 220 -12C353 -12 471 92 471 238C471 357 381 449 274 449C262 449 249 446 233 439L152 404ZM152 374C170 384 202 393 230 393C313 393 382 326 382 213C382 97 330 26 246 26C194 26 165 62 158 81C154 91 152 101 152 116V374Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.669,0)"><path d="M433 39L423 65C413 59 399 54 387 54C370 54 352 69 352 114V299C352 352 342 392 307 422C285 440 255 449 225 449C168 437 102 399 75 379C56 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BioMed Research International

fig7

Figure 7

Figure 7: hnRNPC Promotes Malignancy in Pancreatic Cancer through Stabilization of IQGAP3 