Identifying miRNAs Associated with the Progression of Keloid through mRNA-miRNA Network Analysis and Validating the Targets of miR-29a-3p in Keloid Fibroblasts
Table 3
The characteristics of the datasets included in the analysis.
GEO datasets
Library strategy
Cases
Overall design
Function in the analysis
GSE92566
Microarray
3 keloid patients
The transcriptional profile of biopsies from large chronic keloids, adjacent nonlesional skin ()
Discovery datasets for summarizing the significantly DEGs
GSE83286
Microarray
3 keloid patients
Microarray analysis was used to determine the expression profiles of lncRNAs and mRNAs between 3 pairs of earlobe keloid and normal specimens
GSE158395
RNA-seq
3 keloid patients
The transcriptional profiling of lesional and nonlesional keloid skin
GSE190626
RNA-seq
3 keloid patients
The transcriptional profiling of keloid tissue and adjacent normal tissues
GSE113619
RNA-seq
8 keloid-prone individuals and 6 healthy individuals
3 mm punch biopsies of nonlesional upper outer buttock skin, followed by an additional 4 mm punch biopsy of the same site 6 weeks later (RNA-seq)
Validation dataset to validate the mRNA expression levels
GSE113620
Microarray
8 keloid-prone individuals and 6 healthy individuals
3 mm punch biopsies of nonlesional upper outer buttock skin, followed by an additional 4 mm punch biopsy of the same site 6 weeks later (miRNA)
Validation dataset to validate the miRNA expression levels
GSE188952
RNA-seq
4 keloid patients, 5 hypertrophic scars patients, and 3 normal scars patients
RNA-seq of normal scar, hypertrophic scar, and keloid
Evaluation of the diagnostic value of key genes in keloid
