[Retracted] Albiflorin Alleviates Ox-LDL-Induced Human Umbilical Vein Endothelial Cell Injury through IRAK1/TAK1 Pathway

<div>AF dramatically suppressed IRAK1-TAK1 and apoptosis and induced mitochondrial fusion in Ox-LDL-induced HUVECs. (a) After 4 <i>μ</i>M (AF-L) or 100 <i>μ</i>M (AF-H) of AF induction, the levels of p-IRAK1, IRAK1, p-TAK1, and TAK1 were identified through western blotting analysis in 100 mg/L Ox-LDL-stimulated HUVECs. “1” and “2” are representative of three biological repetitions. (b) Western blotting analysis of apoptosis-related proteins (Bax and caspase 3) and mitochondrial fusion-related proteins (MFN1, MFN2, and OPA1) in 100 mg/L Ox-LDL-induced HUVECs after 4 <i>μ</i>M AF (AF-L) and 100 <i>μ</i>M AF (AF-H) treatment. “1” and “2” are representative of three biological repetitions. (c) The expression and location of p-TAK1 were verified via IF assay in Ox-LDL-induced HUVECs after processing with AF. 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BioMed Research International

fig2

Figure 2

Figure 2: [Retracted] Albiflorin Alleviates Ox-LDL-Induced Human Umbilical Vein Endothelial Cell Injury through IRAK1/TAK1 Pathway 