Predicting Mismatch-Repair Status in Rectal Cancer Using Multiparametric MRI-Based Radiomics Models: A Preliminary Study

Table 1

Demographic and pathological data of the patients in both cohorts.

Variables	CH cohort		value	RJ cohort		value
	dMMR ()	pMMR ()		dMMR ()	pMMR ()
Gender (male/female)	16/4	56/35	0.117	7/4	36/18	1.000
Age (year)			0.775			0.881
BMI (kg/m^2)			0.660			0.747
Histological type
Adenocarcinoma	13	73	0.238	7	41	0.639
Mucinous adenocarcinoma	7	18		4	13
Pathological T stage
T1-2	7	32	0.989	4	20	1.000
T3-4	13	59		7	34
Pathological N stage
N0	8	35	0.898	5	25	0.959
N1-2	12	56		6	29
Clinical M stage
M0	4	26	0.434	3	16	1.000
M1	16	65		8	36
Tumor location
Upper	3	8	0.700	2	10	0.589
Middle	11	53		8	32
Lower	6	30		1	12
Differentiation
Well	3	14	0.213	1	10	0.330
Moderate	14	46		8	26
Poor	3	31		2	18
Tumor deposit
No	13	62	0.786	7	28	0.475
Yes	7	29		4	26
Lymphovascular invasion
No	12	47	0.498	8	29	0.408
Yes	8	44		3	25
Perineural invasion
No	12	63	0.425	5	30	0.540
Yes	8	28		6	24
Tumor budding
No	11	66	0.124	6	35	0.764
Yes	9	25		5	19
KRAS
Wild type	12	67	0.223	6	33	0.946
Mutant type	8	24		5	21
NRAS
Wild type	13	58	0.915	8	30	0.473
Mutant type	7	33		3	24
BRAF
Wild type	11	52	0.861	7	28	0.475
Mutant type	9	39		4	26
CEA
<5 ng/ml	14	52	0.289	8	32	0.619
≥5 ng/ml	6	39		3	22
CA19-9
<37 U/ml	15	77	0.480	10	39	0.354
≥ 37 U/ml	5	14		1	15

CH cohort: Changhai Hospital, training and test sets; RJ cohort: Ruijin Hospital Luwan Branch, validation set; BMI: body mass index; dMMR: deficient mismatch repair; pMMR: proficient mismatch repair; CEA: carcinoembryonic antigen; CA19-9: carbohydrate antigen 19-9. Postoperative blood samples.