Bioinformatic Analysis of the Effect of Silver Nanoparticles on Colorectal Cancer Cell Line

Table 1

Selected literature.

Title	Nanoparticle size	Functionality	Synthesis method	Dosing	Proteins identified	Author and year
Proteomic responses of human intestinal Caco-2 cells exposed to silver nanoparticles and ionic silver	14 nm	Surfactant-coated stabilized with polyethylene glycol-25 (PEG-25) glyceryl trioleate (Tagat TO V) and polyethylene glycol-20 (PEG-20) sorbitan monolaurate (Tween20TM),	AgPURE™ from rent a scientist GmbH (Regensburg, Germany)	2.5 and 25 μg/mL for 24 h	169	Oberemm et al., 2016 [45]
Effects of silver nanoparticles and ions on a coculture model for the gastrointestinal epithelium	20 and 200 nm	Not indicated	Were obtained from plasma-Chem GmbH (Berlin, Germany).	1 mg/L AgNPs-20, AgNPs-200 nm for 24 h	61	Georgantzopoulou et al., 2016 [46]
Protein corona analysis of silver nanoparticles links to their cellular effects	11.1 nm in aquarius stock and 21.3 nm in cell culture medium.	Surfactant-coated	AgPURE™ from rent a scientist GmbH (Regensburg, Germany).	25 μg/mL for 24 h	54	Juling et al., 2017 [47]
Proteomics study of silver nanoparticles on Caco-2 cells	30 nm	Citrate stabilized	Reduction of AgNO3 with citrate and tannic acid	1 or 10 μg/mL for 24 or 72 h	614	Gioria et al., 2018 [26]

The experiments of this research were carried out using cocultures (Caco-2/TC7 and HT29-MTX) so the results of proteomic studies are not only of the Caco-2 cell line.