Bioinformatic Analysis of the Effect of Silver Nanoparticles on Colorectal Cancer Cell Line

Table 2

Functional enrichment analysis of deregulated proteins by exposure to AgNPs in Caco-2 cell.

Category	Term	Genes	value	FDR
GOTERM_BP_DIRECT	Cell-cell adhesion	ANXA2, ENO1, EPS15L1, EEF2, FLNB, HSPA1A, KRT18, PRDX6	3.1-06	9.6-04
	Gluconeogenesis	ALDOC, ENO1, GOT2, GAPDH	1.5-4	2.4-2
GOTERM_CC_DIRECT	Extracellular exosome	NDUFA13, TUFM, ACTB, ACTA2, AHCY, ALDOC, ANXA2, ANXA4, CROCC, ENO1, EEF2, FLNB, GOT2, GSS, GAPDH, HMCN1, KRT18, KRT8, PRDX6, PSMA5, PDIA3, PPA1, SERPINH1, SPEN, TGFBR3	3.1-10	3.5-8
	Cytoplasm	ERC2, NDUFA13, SENP1, ACTB, ACTA2, AHCY, ANXA4, CFAP54, CROCC, ENO1, EEF2, FLNB, GLUD1, GAPDH, HSPA1A, IGF2BP1, KRT18, KRT8, PRDX6, PSMA5, PPA1, TGFBR3	1.9-3	4.8-2
	Centriole	SFI1, CENPJ, CROCC, HSPA1A	2.1-3	4.8-2
GOTERM_MF_DIRECT	Cadherin binding involved in cell-cell adhesion	ANXA2, ENO1, EPS15L1, EEF2, FLNB, HSPA1A, KRT18, PRDX6	4.7-6	6.5-4
	Poly(A) RNA binding	TUFM, ANXA2, ENO1, EEF2, FLNB, GOT2, IGF2BP1, KRT18, PDIA3, SERPINH1, SPEN	2.3-4	1.6-2
KEGG_PATHWAY	Carbon metabolism	ALDOC, ENO1, GLUD1, GOT2, GAPDH	3.3-4	2.1-2
	Biosynthesis of amino acids	ALDOC, ENO1, GOT2, GAPDH	1.3-3	3.3-2
	Metabolic pathways	NDUFA13, AHCY, ALDOC, CES1, ENO1, GLUD1, GOT2, GSS, GAPDH, PRDX6, GALNT9	3.3-2	3.3-2