Bioinformatic Analysis of the Effect of Silver Nanoparticles on Colorectal Cancer Cell Line

Table 3

Hub genes with at least ten interactions involved in the effect of AgNPs on the Caco-2 cell line.

Gene symbol	Protein	Function	Degree
GAPDH	Glyceraldehyde-3-phosphate dehydrogenase	This enzyme plays an important role in glycolysis and nuclear functions.	21
ENO1	Alpha-enolase	An enzyme that plays an important role in glycolysis, growth control, tolerance to hypoxia, and allergic responses.	17
ACTB	Actin, cytoplasmic 1	Conserved protein that produces filaments that form networks in the cytoplasm of cells.	15
ATP5A1	ATP synthase subunit alpha, mitochondrial	Enzyme that produces ATP from ADP in the presence of a proton gradient that is generated by electron transport complexes in the respiratory chain.	11
EEF2	Elongation factor 2	It plays an important role in ribosomal translocation in the elongation of translation.	10
PDIA3	Protein disulfide-isomerase A3	Participates in the rearrangement of disulfide bonds in proteins.	10