[Retracted] hsa_circ_0084811 Regulates Cell Proliferation and Apoptosis in Retinoblastoma through miR-18a-5p/miR-18b-5p/E2F5 Axis

<div>H3K27ac activated the expression of circ_0084811 in RB cells. (a) H3K27ac level in the circ_0084811 promoter region was measured through the UCSC database. (b) The interaction between H3K27ac and the circ_0084811 promoter in RB cells was confirmed through ChIP analysis. (c) circ_0084811 expression in cells treated with C646. (d) CBP expression in RB cell lines and normal cell line. (e, f) CBP expression and protein level were decreased by sh-CBP transfection. (g) circ_0084811 expression was measured after CBP was silenced. (h) The binding ability between circ_0084811 promoter and CBP in RB cells was verified by ChIP assay. (i) The enrichment of circ_0084811 promoter in H3K27ac antibody when CBP was downregulated. Each assay went through three biological replicates. 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BioMed Research International

fig2

Figure 2

Figure 2: [Retracted] hsa_circ_0084811 Regulates Cell Proliferation and Apoptosis in Retinoblastoma through miR-18a-5p/miR-18b-5p/E2F5 Axis 