Xiaotan Sanjie Decoction Inhibits Gastric Cancer Cell Proliferation, Migration, and Invasion through lncRNA-ATB and miR-200A

Figure 6

Molecular mechanism of XTSJ. The corresponding mechanism may be related to XTSJ reducing LncRNA-ATB and increasing miR-200a competing with it to reduce the expression of downstream ZEB-1 and reverse EMT. The process of reversing EMT showed decreased expression of Vimentin and N-cadherin associated with mesenchymal phenotype and increased E-cadherin expression associated with an epithelial phenotype. In addition, XTSJ could reduce Bcl-2, increase Bax, Caspase 3, and Caspase 9 to induce apoptosis.