[Retracted] Brusatol Inhibits Proliferation and Metastasis of Colorectal Cancer by Targeting and Reversing the RhoA/ROCK1 Pathway

Figure 6

BRU inhibits the tumorous growth and metastasis in nude mice. Representative image of nude mouse tumor in subcutaneous tumor-forming model of the control group (normal saline) and BRU (2 mg/kg) group (a). Changes in body weight of mice in the control group and BRU group during treatment (b). Representative image of HE staining in tumor tissue (c). Changes in tumor volume and weight were compared between the control group and the BRU group during treatment (d, f). The protein levels of RhoA, ROCK1, E-cadherin, Vimentin, N-cadherin, MMP2, and MMP9 in tumor tissues were analyzed by western blotting (g, h). Body weight changes of the control group and BRU group in the nude mouse model after tail vein injection (h). Metastatic nodules in lung and bowel (i, j). All data were shown as from three independent trials (, vs. control).

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