A Three-mRNA Signature Associated with Pyrimidine Metabolism for Prognosis of BRCA

Table 2

Gene sets enriched in patients with BRCA and their core genes (1108 samples).

GS follow link to MSigDB	Size	NOM value	FDR value	Core gene list	Core enrichment
KEGG_PYRIMIDINE_METABOLISM	61	0.002	0.013	POLD3, NUDT2, POLR3A, RRM2B, TXNRD1, DUT, UPRT, UCK2, POLR1B, POLR2L, POLA1, NT5C, TXNRD2, NME, NME6, PNPT1, UMPS, POLR1C, NME2, NT5C3A, POLR3C, CAD, UCKL1, CMPK2, POLR2D,NME1-NME2, POLR1A, NT5M, ENTPD8, DCK, POLE3, CTPS2, PRIM1,ZNRD1, RRM1, ENTPD6, POLR2I, PRIM2, POLR2K, POLE, PNP,POLR2G, POLD4, POLD1, POLD2, NME3, CTPS1, NME1, ITPA, POLR2J,TYMS, CANT1, NME4, POLA2, TYMP, TK1, POLE2, POLR2H, DTYMK,RRM2, POLR3K	Yes
GO_PYRIMIDINE_CONTAINING_COMPOUND_CATABOLIC_PROCESS	15	0.127	0.127	DUT, APOBEC3A, NT5C, APOBEC3H, NT5C3A, TDG, MBD4, NT5M,UNG, TET3, APOBEC3B, SMUG1, NTHL1, TYMP, DCTPP1	Yes
GO_PYRIMIDINE_CONTAINING_COMPOUND_BIOSYNTHETIC_PROCESS	26	0.12	0.12	DUT, UPRT, UCK2, GPAT4, NME2P1, NME7, PRPS1, NME6, UMPS,NME2, CAD, AGPAT3, UCKL1, CMPK2, DCK, CTPS2, LCLAT1, CDS1,NME3, CTPS1, NME1, TYMS, NME4, TYMP, TK1, DTYMK	Yes
GO_PYRIDINE_CONTAINING_COMPOUND_METABOLIC_PROCESS	15	0.333	0.333	PSAT1, IDO1, SLC5A8, ACMSD, NUDT17, PNPO, NADSYN1, KMO,NAPRT, QPRT, PDXP, IDH2, PARP9, PNP, PARP10	Yes