Minor Recurrent Aphthous Ulcer Management with Hyaluronic Acid Gel in an Italian Cohort: A Double-Blind Randomized Clinical Trial

Table 2

VAS marginal means and standard errors estimated by mixed models.

	Placebo		Test		Differences from placebo
	Mean^^	Se^^	Mean^^	Se^^	Mean	95% CI	value
Day 1	6.86	0.20	6.67	0.19	-0.19	-0.9; 0.5	1.000
Day 2	5.93	0.22	5.33	0.21	-0.60	-1.4; 0.2	0.342
Day 3	5.14	0.16	4.00	0.22	-1.14	-1.9; 0.4	<0.001
Day 4	4.18	0.16	3.11	0.14	-1.07	-1.6; -0.5	<0.001
Day 5	3.21	0.15	2.19	0.19	-1.03	-1.7; -0.4	<0.001
Day 6	2.25	0.18	1.44	0.16	-0.81	-1.5; -0.2	0.006
Day 7	1.18	0.14	0.56	0.11	-0.62	-1.1; -0.1	0.004

^{^}Estimated by mixed model; Bonferroni adjustment.