Minor Recurrent Aphthous Ulcer Management with Hyaluronic Acid Gel in an Italian Cohort: A Double-Blind Randomized Clinical Trial

Table 4

Individuals with improvement rates in test and placebo groups based on the efficacy index values.

Vas	Day 2			Day 3			Day 4			Day 5			Day 6			Day 7
	Placebo	Test		Placebo	Test		Placebo	Test		Placebo	Test		Placebo	Test		Placebo	Test
	(%)			(%)			(%)			(%)			(%)			(%)
Healed	0	0	0.193	0	0	<0.001	0	0	0.023	0	2 (7.4)	0.001	1 (3.6)	4 (14.8)	0.041	5 (17.9)	13 (48.1)	0.017
Marked improvement	0	0		0	0		0	1 (3.7)		1 (3.6)	9 (33.3)		11 (39.3)	16 (59.3)		20 (71.4)	14 (51.9)
Moderate improvement	1 (3.6)	4 (14.8)		6 (21.4)	20 (74.1)		22 (78.6)	26 (96.3)		27 (96.4)	16 (59.3)		16 (57.1)	7 (25.9)		3 (10.7)	0
No improvement	27 (96.4)	23 (85.2)		22 (78.6)	7 (25.9)		6 (21.4)	0		0	0		0	0		0	0
Marked improvement rate	0	0	—	0	0		0	1 (3,7)	0.491	1 (3.6)	11 (40.7)	0.001	12 (42.9)	20 (74.1)	0.019	25 (89.3)	27 (100)	0.072
Improvement rate	1 (3.6)	4 (14.8)	0.193	6 (21.4)	20 (74.1)	<0.001	22 (78.6)	27 (100)	0.023	28 (100)	27 (100)		28 (100)	27 (100)		28 (100)	27 (100)

Chi-square test or Fisher exact test: .