CLK2 Expression Is Associated with the Progression of Colorectal Cancer and Is a Prognostic Biomarker

Table 1

Association with CLK2 expression and clinicopathologic characteristics in TCGA and our validation cohort.

	Total	CLK2 expression
		Low expression	High expression
TCGA cohort
Age
<65	217	119	98	3.423	0.064
≥65	317	148	169
Gender
Female	247	112	135	3.985	0.046
Male	287	132	155
Radiation therapy
No	493	245	248	0.238	0.626
Yes	41	22	19
Chemotherapy
No	322	164	158	0.282	0.596
Yes	212	103	109
Local invasion
T1	19	12	7	12.799	0.005
T2	94	60	34
T3	365	174	191
T4	56	21	35
LN metastasis
N0	303	159	144	5.766	0.056
N1	132	70	62
N2	97	38	59
Distant metastasis
Yes	80	37	43	0.511	0.540
No	399	202	197
TNM stage
Stage I	94	34	60	8.795	0.032
Stage II	197	94	103
Stage III	163	76	87
Stage IV	80	43	37
Validation cohort
Age
<65	15	10	5	0.321	0.571
≥65	35	20	15
Gender
Female	26	14	12	2.381	0.123
Male	24	11	13
Tumor size
<5 cm	26	15	11	1.282	0.258
≥5 cm	24	10	14
Tumor grade
G1 + G2	23	15	8	3.945	0.047
G3	27	10	17
Local invasion
T1 + T2 + T3	23	17	6	9.742	0.002
T4	27	8	19
LN metastasis
Yes	14	10	4	3.571	0.059
No	36	15	21
TNM stage
Stage I/II	14	10	4	3.571	0.059
Stage III	36	15	21

Bold, , demonstrated by chi-square test. Abbreviations: LN: lymph node metastasis.