CLK2 Expression Is Associated with the Progression of Colorectal Cancer and Is a Prognostic Biomarker

Table 3

Univariate and multivariate analysis of clinical features associated with the expression level of CLK2 in colorectal cancer.

Clinical features	Univariate analysis		Multivariate analysis
	HR	value	HR	95% CI	value
Age (≥65 vs. <65)	2.09	0.002	2.70	1.68-4.35	<0.001
Gender (female vs. male)	1.12	0.597	—	—	—
TNM stage (stages III and IV vs. stage III and IV)	3.76	<0.001	1.33	1.13-12.59	0.030
Local invasion (T4 vs. T1-T3)	3.88	<0.001	2.30	1.32-4.02	0.003
Lymph metastasis (yes vs. no)	3.23	<0.001	0.75	0.26-2.19	0.598
Distant metastasis (yes vs. no)	4.35	<0.001	2.30	1.34-3.85	0.002
CLK2 expression (high vs. low)	2.01	0.002	1.71	1.09-2.69	0.019

Note: HR: hazard ratio.