A Novel Inhibitor INF 39 Promotes Osteogenesis via Blocking the NLRP3/IL-1β Axis

Figure 3

INF 39 promotes osteogenesis via inhibiting the NLRP3/IL-1β axis. (a) The concentration of IL-1β in the culture of osteoclasts, IL-1β: interleukin- (IL-) 1β (). (b, c) The gray level of IL-1β in NLRP3 knockdown osteoblasts for 7 d was quantified and normalized to β-tubulin using ImageJ (). (d, e) The gray level of IL-1β in osteoblasts treated with various concentrations of INF 39 for 7 d was quantified and normalized to β-tubulin using ImageJ (). , , and .

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