| | Patients with CSU (%) | value | | Positive ANA () | Negative ANA () |
| | Sex, (%) | | | 0.848 | | Male | 17/100 (17.0) | 36/223 (16.1) | | | Female | 83/100 (83.0) | 187/223 (83.9) | | | Age of onset (year), median (min-max) | 38.2 (8.4-81.4) | 35.4 (7.2-74.9) | 0.042 | | Age of patients’ first visit (year), median (min-max) | 39.2 (12.9-82.1) | 36.9 (15.0-75.9) | 0.033 | | Duration of treatment (year), median (min-max) | 1.73 (0.01-13.74) | 1.21 (0.00-16.15) | 0.101 | | Duration of disease (year), median (min-max) | 2.73 (0.04-23.49) | 2.38 (0.15-41.19) | 0.164 | | Disease severity | | | | | Maximal UAS7, median (min-max) | 18 (1-42) | 16 (2-42) | 0.591 | | Mild, (%) | 25/53 (47.2) | 56/117 (47.9) | | | Moderate, (%) | 16/53 (30.2) | 34/117 (29.1) | | | Severe, (%) | 12/53 (22.6) | 27/117 (23.1) | | | Maximal CU-Q2oL, median (min-max) | 25 (0-83) | 24 (1-82) | 0.873 | | Maximal DLQI, median (min-max) | 5.5 (0-27) | 4 (0-25) | 0.730 | | Cumulative medication score, median (min-max) | 8 (2-34) | 8 (2-29) | 0.152 | | Mild, (%) | 9/98 (9.2) | 23/217 (10.6) | 0.248 | | Moderate, (%) | 66/98 (67.3) | 160/217 (73.7) | | | Severe, (%) | 23/98 (23.5) | 34/217 (15.7) | | | Immunosuppressive drug/biologic drug, (%) | 32/98 (32.7) | 53/217 (24.4) | 0.128 | | Personal history of atopy, (%) | 23/100 (23.0) | 68/223 (30.5) | 0.166 | | Allergic rhinitis, (%) | 13/100 (13.0) | 50/223 (22.4) | 0.048 | | Asthma, (%) | 6/100 (6.0) | 7/223 (3.1) | 0.233 | | Atopic dermatitis, (%) | 1/100 (1.0) | 4/223 (1.8) | 1.000 | | Allergic conjunctivitis, (%) | 1/100 (1.0) | 7/223 (3.1) | 0.443 | | Family history of atopy, (%) | 29/100 (29.0) | 68/223 (30.5) | 0.787 | | Allergic rhinitis, (%) | 10/100 (10.0) | 32/223 (14.3) | 0.283 | | Asthma, (%) | 7/100 (7.0) | 13/223 (5.8) | 0.687 | | Atopic dermatitis, (%) | 0/100 (0.0) | 3/223 (1.3) | 0.555 | | Allergic conjunctivitis, (%) | 0 | 0 | — | | Urticaria/angioedema, (%) | 2/100 (2.0) | 5/223 (2.2) | 1.000 | | Underlying diseases | | | | | Thyroid disease, (%) | 8/100 (8.0) | 12/223 (5.4) | 0.367 | | Diabetes mellitus, (%) | 4/100 (4.0) | 9/223 (4.0) | 1.000 | | Hyperlipidemia, (%) | 2/100 (2.0) | 10/223 (4.5) | 0.355 | | Hypertension, (%) | 7/100 (7.0) | 12/223 (5.4) | 0.568 | | Associated angioedema, (%) | 21/100 (21.0) | 42/223 (18.8) | 0.650 |
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