Research Article

Do Antinuclear Antibodies Influence the Clinical Features of Chronic Spontaneous Urticaria?: A Retrospective Cohort Study

Table 2

Laboratory investigations of patients with chronic spontaneous urticaria (CSU) with positive and negative antinuclear antibodies (ANA).

Patients with CSU value
Positive ANA ()Negative ANA ()

Total eosinophil (cell/microL), median (min-max)113 (13-399)148 (11-746)0.177
Eosinophilia (500 eosinophils/microL), (%)3/71 (4.2%)9/148 (6.1%)0.755
Total white blood cell (cell/microL), median (min-max)6,380 (2,053-13,100)6,385 (2,048-17,220)0.748
Leukopenia (<4,000 white blood cell/microL), (%)22/94 (23.4%)58/206 (28.2%)0.388
Erythrocyte sedimentation rate (ESR) (mm/hr) (), median (min-max)18 (4-84)14 (1-60)0.007
Stool exam: Blastocystis hominis, (%)1/42 (2.4%)4/85 (4.7%)1.00
HBsAg (positive), (%)1/57 (1.8%)5/127 (3.9%)0.668
Anti HCV (positive), (%)2/52 (3.8%)0/104 (0.0%)0.110
Thyroid microsomal antibody (positive), (%)1/15 (6.7%)3/30 (10.0%)1.000
Antithyroid peroxidase (anti-TPO) (positive), (%)8/40 (20.0%)11/75 (14.7%)0.463
Antithyroglobulin antibody (positive), (%)15/52 (28.8%)22/109 (20.2%)0.222
T3, (%)0.713
 Low2/19 (10.5%)7/45 (15.6%)
FT4, (%)0.614
 Low3/24 (12.5%)2/42 (4.8%)
 High1/24 (4.2%)2/42 (4.8%)
TSH, (%)0.834
 Low1/58 (1.7%)5/122 (4.1%)
 High3/58 (5.2%)7/122 (5.7%)
D-dimer (>500 ng/mL), (%)7/14 (50.0%)14/37 (37.8%)0.431
IgE (>100 IU/mL), (%)13/18 (72.2%)22/38 (57.9%)0.301
Autologous serum skin test (positive), n (%)4/18 (22.2%)14/39 (35.9%)0.302
Skin prick pest (positive), (%)6/15 (40.0%)26/45 (57.8%)0.232

indicated statistical significance.