hsa-miR-206b Involves in the Development of Papillary Thyroid Carcinoma via Targeting LMX1B

Figure 1

The mRNA and miRNA profiles of different disease stage groups (stage III_IV, ; stage I_II, ) based on PTC data from TCGA-THCA data collection. (a) Hierarchical clustering of differentially expressed mRNAs in the stage III_IV group () versus the stage I_II group (). For each gene (row), the red color indicates a higher expression and the blue color indicates a lower expression when compared with the average expression level of that gene across the 493 samples. (b) Volcano plot of mRNA profiles based on the comparison between the stage III_IV group () and the stage I_II group (). There were 294 differentially expressed genes (filtering criteria: and ), of which 202 were upregulated and 92 were downregulated. (c) Hierarchical clustering of differentially expressed miRNAs in the stage III_IV group () versus the stage I_II group (). For each gene (row), the red color indicates a higher expression and the blue color indicates a lower expression when compared with the average expression level of that gene across the 493 samples. (d) Volcano plot of miRNA profiles based on the comparison between the stage III_IV group () and the stage I_II group (). There were 36 differentially expressed genes (filtering criteria: and ), of which 31 were upregulated and 5 were downregulated.

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