GRWR Correlates with the Metabolism of Tacrolimus after Pediatric Living Donor Liver Transplantation According to Donor CYP3A5 Polymorphism

Table 7

Uni- and multivariate analyses of variables that significantly affected TAC C/D ratios 3, 7, 14, and 30 days after LT.

Significant variables	Univariate analysis		Multivariate analysis
	value	value	value	value
Recipient age	15.907	<0.001	/	/
Recipient weight	11.064	<0.001	/	/
Recipient height	10.150	0.002	/	/
PELD score	6.096	0.001	/	/
GRWR	17.105	<0.001	4.631	0.033
Donor CYP3A5	12.311	0.001	11.876	0.01
Recipient CYP3A5	21.781	<0.001	/	/
Donor ABO blood group	2.874	0.038	/	/

Note: GRWR: graft-to-recipient weight ratio; PELD: pediatric end-stage liver disease; TAC: tacrolimus; C/D: concentration-dose; LT: liver transplantation.