[Retracted] Alpha Protein Kinase 2 Promotes Esophageal Cancer via Integrin Alpha 11

<div>ALPK2 depletion impaired esophageal cancer development via the downregulation of ITGA11. (a) The coexpressed genes of ALPK2 were predicted via analyzing the Coexpedia website. (b) The levels of PAPPA, ITGA11, and RAB31 were assessed in ESCA samples from TCGA database using the UALCAN website. (c) The association between PAPPA, ITGA11, and RAB31 with ALPK2 was constructed with the ENCORI website. (d) Eca-109 cell proliferation was tested after being transfected with shPAPPA, shITGA11, and shRAB31. The viability and migration of (e) Eca-109 and (f) TE-1 cells were measured in different groups. NC (OE+KD) as negative control; ITGA11+NC-shALPK2 as overexpressed ITGA11; shALPK2+NC-ITGA11 as ALPK2 downregulation; ITGA11+shALPK2 as simultaneously downregulated ALPK2 and overexpressed ITGA11. 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BioMed Research International

fig5

Figure 5

Figure 5: [Retracted] Alpha Protein Kinase 2 Promotes Esophageal Cancer via Integrin Alpha 11 