Validated HPLC-UV Method for Simultaneous Estimation of Paclitaxel and Doxorubicin Employing Ion Pair Chromatography: Application in Formulation Development and Pharmacokinetic Studies

Table 1

Regression curve parameters for PTX and DOX.

Parameters	PTX	DOX
Range of calibration curve (μg/ml)	0.039-10	0.039-10
Detection wavelength (nm)	231	231
Retention time (minute)	4.4	7.2
Correlation coefficient ()	0.9999	0.9999
Slope	39770	67733
Intercept	363.17	-1818.20
LOQ (μg/ml)	0.066	0.038
LOD (μg/ml)	0.021	0.012