Validated HPLC-UV Method for Simultaneous Estimation of Paclitaxel and Doxorubicin Employing Ion Pair Chromatography: Application in Formulation Development and Pharmacokinetic Studies

Table 2

Accuracy and precision of the method.

Nominal concentration (μg/ml)	Intraday		Interday		Plasma
	Accuracy (% recovery)	Precision (% RSD)	Accuracy (% recovery)	Precision (% RSD)	Recovery (%)	% RSD
PTX
0.5	99.27	0.89	99.51	0.947	87.74	4.79
1	100.74	0.24	100.46	1.428	85.41	1.34
1.5	99.88	1.07	99.43	1.088	93.96	1.06
DOX
0.5	100.20	0.12	100.03	1.494	89.11	0.58
1	100.93	0.65	100.40	1.081	90.88	2.73
1.5	99.98	0.13	100.46	1.232	86.82	0.73