Validated HPLC-UV Method for Simultaneous Estimation of Paclitaxel and Doxorubicin Employing Ion Pair Chromatography: Application in Formulation Development and Pharmacokinetic Studies

Table 5

Plasma pharmacokinetic parameters of PTX and DOX following intravenous administration of liposomal formulation loaded with PTX and DOX in Balb/c mice.

Pharmacokinetic parameters	PTX (10 mg/kg)	DOX (6 mg/kg)
(μg/ml)	3.67	1.20
(h)	3.57	3.45
Clearance (ml/h/kg)	1.20	3.23
AUC0-∞ (h/μg/ml)	8.29	1.85
Mean residence time (h)	6.33	3.89