The Expression and Survival Significance of FOXD1 in Lung Squamous Cell Carcinoma: A Meta-Analysis, Immunohistochemistry Validation, and Bioinformatics Analysis

Table 3

Univariate and multivariate Cox regression analysis for clinical factors in LUSC patients.

Variables	Univariate analysis		Multivariate analysis
	HR (95% CI)	P value	HR (95% CI)	P value
Age (>60/<=60 years)	1.242 (0.871-1.772)	0.232	1.866 (1.205-2.891)	0.005
Gender (male/female)	1.196 (0.868-1.647)	0.275
Distant metastasis (M1/M0)	3.099 (1.266-7.584)	0.013	2.512 (1.021-6.179)	0.045
Clinical stage (IV/III/II/I)	1.557 (1.131-2.144)	0.007
Tumor size (T4/T3/T2/T1)	1.651 (1.195-2.281)	0.002	1.516 (1.042-2.205)	0.030
Node metastasis (N3/N2/N1/N0)	1.134 (0.858-1.499)	0.376
Smoking (heavy/light)	0.656 (0.494-0.872)	0.004
FOXD1 expression (high/low)	0.750 (0.572-0.983)	0.037	0.706 (0.522-0.956)	0.024