Overexpression of CISD1 Predicts Worse Survival in Hepatocarcinoma Patients

Figure 5

Gene epigenetic regulation leads to high expression of CISD1 in HCC. (a) Decreased CISD1 promoter methylation in datasets of hepatocarcinomas compared with normal tissues in the Oncomine database. (b) Methylation of the CISD1 promoter is lower in HCC than that in normal tissue in TCGA LICH dataset collected by UALCAN. (c) mRNA expression of CISD1 is positively correlated with DNMT1 mRNA expression in TCGA LIHC cohort. (d) mRNA expression of CISD1 is positively correlated with DNMT2 mRNA expression in TCGA LIHC cohort. (e) mRNA expression of CISD1 is positively correlated with DNMT3A mRNA expression in TCGA LIHC cohort. (f) mRNA expression of CISD1 is not related to DNMT3B mRNA expression in TCGA LIHC cohort.

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