Clinical Prediction Nomograms to Assess Overall Survival and Disease-Specific Survival of Patients with Salivary Gland Adenoid Cystic Carcinoma

Table 2

Multivariate cox regression analysis of various factors associated with overall and disease specific survival in patients with salivary gland adenoid cystic carcinoma.

Characteristic	OS		DSS
	HR (95% CI)		HR (95% CI)
Age		<0.001
<40 years	Reference
40-49 years	1.153 (0.617-2.155)	0.655
50-59 years	0.930 (0.494-1.751)	0.823
60-69 years	1.632 (0.906-2.939)	0.103
≥70 years	2.377 (1.342-4.211)	0.003
T stage		<0.001		<0.001
T1	Reference		Reference
T2	1.160 (0.667-2.016)	0.599	0.880 (0.452-1.715)	0.708
T3	2.429 (1.445-4.085)	<0.001	2.493 (1.399-4.444)	0.002
T4a	2.420 (1.441-4.064)	<0.001	2.609 (1.452-4.687)	0.001
T4b	3.388 (1.794-6.400)	<0.001	3.198 (1.575-6.495)	0.001
N stage		0.001		0.001
N0	Reference		Reference
N1	0.997 (0.585-1.701)	0.992	1.094 (0.621-1.927)	0.756
N2+N3	1.993 (1.282-3.096)	0.002	2.092 (1.306-3.351)	0.002
M stage		<0.001		<0.001
M0	Reference		Reference
M1	3.084 (1.871-5.083)	<0.001	3.124 (1.885-5.178)	<0.001
Histologic grade		<0.001		<0.001
Low-grade transformation	Reference		Reference
Intermediate-grade transformation	1.847 (1.040-3.282)	0.036	1.656 (0.852-3.220)	0.137
High-grade transformation	5.081 (2.816-9.168)	<0.001	5.983 (3.074-11.643)	<0.001
High-grade transformation	5.104 (2.789-9.341)	<0.001	5.723 (2.8860 11.3490)	<0.001
Surgery		<0.001		<0.001
No	Reference		Reference
Yes	0.384 (0.221-0.668)	<0.001	0.283 (0.156-0.511)	<0.001