Research Article

[Retracted] Deep Fusion of Intelligent Meridian Sensing Technology and Huoluo Xiaoling Pills in the Treatment of Knee Osteoarthritis

Table 3

Related pathways of Huoluo Xiaoling Pill in the treatment of knee osteoarthritis.

Channel number valuePathway nameParticipating gene

hsa04657-30.549IL-17 signaling pathwayCASP3, CASP8, CHUK, MAPK14, FOS, CXCL2, GSK3B, HSP90AA1, IFNG, IL1B, CXCL8, CXCL10, JUN, MMP1, MMP3, MMP9, NFKBIA, MAPK1, PTGS2, RELA, CCL2
hsa04668-30.4926TNF signaling pathwayAKT1, CASP3, CASP7, CASP8, CHUK, MAPK14, FOS, CXCL2, ICAM1, IL1B, CXCL10, JUN, MMP3, MMP9, NFKBIA, MAPK1, PTGS2, RELA, CCL2, SELE, VCAM1
hsa05169-26.7835Epstein-Barr virus infectionAKT1, BAX, CCND1, BCL2, CASP3, CASP8, CASP9, CDK, CDK4, CDKN1A, CHUK, MAPK14, E2F1, GSK3B, HSPB1, ICAM, IFNG, CXCL10, JUN, MDM2, MYC, NFKBIA, RELA, STAT1, STAT3, TP53
hsa04151-22.7152PI3K-Akt signaling pathwayAKT1, CCND1, BCL2, BCL2L1, CASP9, CDK4, CDKN1A, CHUK, EGFR, GSK3B, HSP90AA1, IL2, IL4R, ITGB3, MDM2, MET, MYC, NOS3, PRKCA, MAPK1, RELA, SPP1, TP53
hsa04210-22.6584ApoptosisPARP1, AKT1, XIAP, BIRC5, BAX, BCL2, BCL2L1, CASP3, CASP7, CASP8, CASP9, CHUK, CTSD, FOS, JUN, NFKBIA, MAPK1, RELA, TP53
hsa04066-21.2695HIF-1 signaling pathwayAKT1, BCL2, CDKN1A, EGFR, ERBB2, F3, HIF1A, HK2, HMOX1, IFNG, NOS2, NOS3, SERPINE1, PRKCA, MAPK1, RELA, STAT3
hsa04115-20.7752p53 signaling pathwayBAX, CCND1, BCL2, BCL2L1, CASP3, CASP8, CASP9, CCNB1, CDK1, CDK4, CDKN1A, IGFBP3, MDM2, SERPINE1, TP53
hsa04064-18.6693NF-kappa B signaling pathwayPARP1, XIAP, BCL2, BCL2L1, CD40LG, CHUK, CXCL2, ICAM1, IL1B, CXCL8, NFKBIA, PLAU, PTGS2, RELA, VCAM1
hsa04620-18.419Toll-like receptor signaling pathwayAKT1, CASP8, CHUK, MAPK14, FOS, IL1B, CXCL8, CXCL1, JUN, NFKBIA, MAPK1, RELA, CXCL11, SPP1, STAT1
hsa04380-16.9517Osteoclast differentiationAKT1, CALCR, CHUK, MAPK14, FOS, IFNG, IL1A, IL1B, ITGB3, JUN, NFKBIA, PPARG, MAPK1, RELA, STAT1
hsa04621-16.412NOD-like receptor signaling pathwayXIAP, BCL2, BCL2L1, CASP8, CHUK, MAPK14, CXCL2, HSP90AA1, IL1B, CXCL8, JUN, NFKBIA, MAPK1, RELA, CCL2, STAT1
hsa04010-15.1529MAPK signaling pathwayAKT1, CASP3, CHUK, MAPK14, EGFR, ERBB2, FOS, HSPB, IGF2, IL1A, IL1B, JUN, MET, MYC, PRKCA, MAPK1, RELA, TP53