Melatonin Ameliorates the Progression of Alzheimer’s Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity

Figure 1

(a) Compared with placebo control APP/PS1 transgenic mice, the escape latency of the melatonin (MT) intervention group was shortened. (b) The escape latency was significantly different on day 5. (c) Compared with placebo control APP/PS1 transgenic mice, the number of platform crossings significantly increased in the MT intervention group. (d) The time in the target quadrant of the MT intervention group was significantly increased. (e) There was no significant statistical difference in swimming speed between the placebo control and MT intervention groups. (f) The number of senile plaques in the cerebral cortex was measured by thioflavin sulfur staining in APP/PS1 transgenic mice with TM treatment. The relative plaque burden ratio is shown on the left. (g) The number of senile plaques in the hippocampus was measured by thioflavin sulfur staining in APP/PS1 transgenic mice with TM treatment. The relative plaque burden ratio is shown on the left. in each group. Data are presented as . ; ; .

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