Melatonin Ameliorates the Progression of Alzheimer’s Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity

<div>(a) Immunofluorescence analysis of the nuclear translocation of TFEB in SH-SY5Y cells incubated with MT. (b) Western blotting analysis of the nuclear translocation of TFEB in SH-SY5Y cells incubated with MT. (c) shRNA knockdown of TFEB was performed in combination with A<i>β</i>25-35 and MT treatment, and the expressions of TFEB, Parkin, p62, and caspase-1 were detected by western blotting. (d) shRNA knockdown of TFEB was performed in combination with A<i>β</i>25-35 and MT treatment, and the lever of ROS was detected by luminol chemiluminescence kit. (e) shRNA knockdown of TFEB was performed in combination with A<i>β</i>25-35 and MT treatment, and the expression of IL-1<i>β</i> and IL-18 was analysed. 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BioMed Research International

fig5

Figure 5

Figure 5: Melatonin Ameliorates the Progression of Alzheimer’s Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity 

Figure 5 | Melatonin Ameliorates the Progression of Alzheimer’s Disease by Inducing TFEB Nuclear Translocation, Promoting Mitophagy, and Regulating NLRP3 Inflammasome Activity 