Kahweol Protects against Acetaminophen-Induced Hepatotoxicity in Mice through Inhibiting Oxidative Stress, Hepatocyte Death, and Inflammation

Figure 4

Effects of kahweol on hepatocyte death and ER stress in APAP-treated mice. (a) TUNEL staining. Nuclei were counterstained with DAPI (blue).  μm. (b) Number of TUNEL-stained cells per field. (c) Hepatic mRNA levels of ATF4, ATF6, and GRP78. (d) Western blotting of XBP1s, p-eIF2α, and CHOP in liver tissues. (e) Quantification of western blot data for XBP1s, p-eIF2α, and CHOP. (f) IHC staining for CHOP.  μm. (g) Percentage of CHOP-stained area. per group. , , and vs. control. ^# and ^### vs. APAP.

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