SNORD15B and SNORA5C: Novel Diagnostic and Prognostic Biomarkers for Colorectal Cancer

Table 3

Cox regression analysis for SNORD15B and overall survival of CRC.

Variables	HR	Univariate		HR	Multivariate
		95% CI			95% CI
Sex (female vs. male)	1.010	0.669–1.524	0.964	—	—	—
Age (≤ 70 vs. > 70)	1.808	1.188–2.753	0.006	2.003	1.232–3.255	0.005
TNM stage (stage I/II vs. stage III/IV)	3.613	2.280–5.726	<0.001	4.767	2.661–8.540	< 0.001
Lymphatic invasion (negative vs. positive)	2.256	1.449–3.513	<0.001	0.848	0.462–1.557	0.595
Venous invasion (negative vs. positive)	2.376	1.505–3.751	< 0.001	1.696	0.949–3.032	0.075
History of colon polyps (negative vs. positive)	0.768	0.447–1.321	0.340	—	—	—
SNORD15B expression (low vs. high)^#	1.651	1.081–2.522	0.020	2.198	1.334–3.622	0.002

^#Cutoff threshold of SNORD15B expression was median value in all patients in this cohort. .