SNORD15B and SNORA5C: Novel Diagnostic and Prognostic Biomarkers for Colorectal Cancer

Table 4

Cox regression analysis for SNORA5C and overall survival of CRC.

Variables	HR	Univariate		HR	Multivariate
		95% CI			95% CI
Sex (female vs. male)	1.010	0.669–1.524	0.964	—	—	—
Age (≤ 70 vs. > 70)	1.808	1.188–2.753	0.006	1.995	1.228–3.243	0.005
TNM stage (stage I/II vs. stage III/IV)	3.613	2.280–5.726	<0.001	4.379	2.447–7.836	<0.001
Lymphatic invasion (negative vs. positive)	2.256	1.449–3.513	<0.001	0.884	0.471–1.661	0.702
Venous invasion (negative vs. positive)	2.376	1.505–3.751	< 0.001	1.435	0.785–2.626	0.241
History of colon polyps (negative vs. positive)	0.768	0.447–1.321	0.340	—	—	—
SNORA5C expression (low vs. high)^#	1.608	1.053–2.456	0.028	2.128	1.278–3.545	0.004

^#Cutoff threshold of SNORA5C expression was median value in all patients in this cohort; .