Predicting Hypertensive Disease in the First Trimester of Pregnancy: Risk Models and Analysis of Serum D-dimer Levels Combined with Plasma Pregnancy-Associated Protein A, Free β-Subunit of Human Chorionic Gonadotropin, and Fetal Nuchal Translucency
Table 3
Predicting value of DD, PAPP-A, and free β-hCG in separate or joint screening for GH, PE, SPE, and HDP.
Screening indicators
Groups ()
AUC
95% CI
Cut-off
Sensitivity
Specificity
Youden index
GH ()
DD
0.699
0.637-0.760
<0.001
0.725
0.992
0.353
0.345
PAPP-A
0.507
0.439-0.575
0.842
0.560
0.873
0.180
0.053
Free β-hCG
0.563
0.495-0.630
0.073
1.215
0.738
0.413
0.151
NT
0.512
0.440-0.585
0.736
0.825
0.730
0.336
0.066
DD+PAPP-A
0.700
0.639-0.760
<0.001
0.479
0.976
0.393
0.370
DD+free β-hCG
0.706
0.646-0.766
<0.001
0.551
0.960
0.393
0.354
PAPP-A+free β-hCG
0.582
0.515-0.649
0.019
1.047
0.667
0.520
0.187
DD+PAPP-A+free β-hCG
0.735
0.677-0.792
<0.001
1.750
0.659
0.700
0.359
PAPP-A+free β-hCG+NT
0.605
0.535-0.675
0.004
1.028
0.704
0.481
0.185
DD+PAPP-A+free β-hCG+NT
0.733
0.676-0.795
<0.001
0.461
0.965
0.420
0.385
PE ()
DD
0.784
0.718-0.850
<0.001
0.815
0.962
0.467
0.429
PAPP-A
0.510
0.420-0.600
0.830
0.725
0.774
0.313
0.087
Free β-hCG
0.585
0.497-0.673
0.067
1.370
0.868
0.340
0.208
NT
0.530
0.435-0.624
0.535
1.035
0.725
0.405
0.130
DD+PAPP-A
0.764
0.699-0.829
<0.001
0.474
0.925
0.513
0.438
DD+free β-hCG
0.773
0.709-0.838
<0.001
0.650
0.906
0.567
0.472
PAPP-A+free β-hCG
0.574
0.484-0.664
0.109
0.876
0.698
0.447
0.145
DD+PAPP-A+free β-hCG
0.795
0.734-0.857
<0.001
0.670
0.887
0.607
0.493
PAPP-A+free β-hCG+NT
0.595
0.503-0.686
0.048
1.153
0.431
0.740
0.172
DD+PAPP-A+free β-hCG+NT
0.808
0.745-0.871
<0.001
1.149
0.843
0.687
0.530
SPE ()
DD
0.893
0.848-0.939
<0.001
0.945
1.000
0.660
0.660
PAPP-A
0.592
0.488-0.696
0.071
0.955
0.683
0.500
0.183
Free β-hCG
0.572
0.474-0.671
0.156
1.015
0.659
0.533
0.192
NT
0.645
0.548-0.743
0.009
0.855
0.618
0.641
0.259
DD+PAPP-A
0.897
0.853-0.940
<0.001
0.615
0.951
0.727
0.678
DD+free β-hCG
0.874
0.825-0.922
<0.001
0.734
0.951
0.747
0.698
PAPP-A+free β-hCG
0.619
0.517-0.721
0.020
1.071
0.439
0.767
0.206
DD+PAPP-A+free β-hCG
0.904
0.862-0.946
<0.001
1.188
0.902
0.813
0.716
PAPP-A+free β-hCG+NT
0.733
0.642-0.825
<0.001
0.696
0.824
0.542
0.366
DD+PAPP-A+free β-hCG+NT
0.931
0.892-0.970
<0.001
1.634
0.912
0.878
0.790
HDP ()
DD
0.755
0.704-0.807
<0.001
0.915
0.755
0.640
0.395
PAPP-A
0.511
0.451-0.571
0.725
1.355
0.782
0.267
0.048
Free β-hCG
0.570
0.510-0.630
0.023
1.160
0.691
0.453
0.144
NT
0.525
0.461-0.589
0.440
1.035
0.675
0.405
0.080
DD+PAPP-A
0.711
0.656-0.767
<0.001
0.354
0.982
0.367
0.348
DD+free β-hCG
0.719
0.664-0.774
<0.001
0.372
0.982
0.367
0.348
PAPP-A+free β-hCG
0.558
0.489-0.618
0.056
0.887
0.823
0.280
0.103
DD+PAPP-A+free β-hCG
0.756
0.704-0.807
<0.001
1.177
0.809
0.600
0.409
PAPP-A+free β-hCG+NT
0.587
0.525-0.649
0.007
0.853
0.830
0.321
0.151
DD+PAPP-A+free β-hCG+NT
0.753
0.698-0.808
<0.001
0.865
0.855
0.542
0.397
DD: D-dimer; PAPP-A: pregnancy-associated plasma protein A; free β-hCG: free beta human chorionic gonadotropin; NT: nuchal translucency; MoM: multiple of the median; GH: gestational hypertension; PE: preeclampsia; SPE: severe preeclampsia; HDP: hypertensive disorders of pregnancy; AUC: area under the curve; LR: likelihood ratio. ;.
