Predicting Hypertensive Disease in the First Trimester of Pregnancy: Risk Models and Analysis of Serum D-dimer Levels Combined with Plasma Pregnancy-Associated Protein A, Free β-Subunit of Human Chorionic Gonadotropin, and Fetal Nuchal Translucency
Table 4
The value evaluation for the risk models.
Screening indicators
Groups ()
FPR
FNR
PPV
NPV
+LR
-LR
GH ()
DD
0.647
0.008
0.563
0.981
1.534
0.022
PAPP-A
0.820
0.127
0.472
0.628
1.065
0.705
Free β-hCG
0.587
0.262
0.514
0.653
1.258
0.634
NT
0.664
0.270
0.491
0.587
1.100
0.803
DD+PAPP-A
0.607
0.024
0.575
0.952
1.609
0.061
DD+free β-hCG
0.607
0.040
0.571
0.922
1.583
0.101
PAPP-A+free β-hCG
0.480
0.333
0.538
0.650
1.389
0.641
DD+PAPP-A+free β-hCG
0.300
0.341
0.648
0.709
2.196
0.488
PAPP-A+free β-hCG+NT
0.519
0.296
0.544
0.649
1.357
0.615
DD+PAPP-A+free β-hCG+NT
0.580
0.035
0.594
0.932
1.664
0.083
PE ()
DD
0.533
0.038
0.389
0.972
1.804
0.081
PAPP-A
0.687
0.226
0.285
0.797
1.127
0.723
Free β-hCG
0.660
0.132
0.317
0.879
1.315
0.388
NT
0.595
0.275
0.322
0.791
1.218
0.679
DD+PAPP-A
0.487
0.075
0.402
0.951
1.900
0.147
DD+free β-hCG
0.433
0.094
0.425
0.944
2.090
0.166
PAPP-A+free β-hCG
0.553
0.302
0.308
0.807
1.262
0.676
DD+PAPP-A+free β-hCG
0.393
0.113
0.443
0.938
2.255
0.187
PAPP-A+free β-hCG+NT
0.260
0.569
0.393
0.770
1.662
0.768
DD+PAPP-A+free β-hCG+NT
0.313
0.157
0.512
0.918
2.694
0.228
SPE ()
DD
0.340
0
0.446
1.000
2.941
0
PAPP-A
0.500
0.317
0.272
0.852
1.366
0.634
Free β-hCG
0.467
0.341
0.278
0.851
1.411
0.640
NT
0.359
0.382
0.309
0.866
1.722
0.596
DD+PAPP-A
0.273
0.049
0.487
0.982
3.480
0.067
DD+free β-hCG
0.253
0.049
0.506
0.982
3.755
0.065
PAPP-A+free β-hCG
0.233
0.561
0.340
0.833
1.882
0.732
DD+PAPP-A+free β-hCG
0.187
0.098
0.569
0.968
4.834
0.120
PAPP-A+free β-hCG+NT
0.458
0.176
0.318
0.922
1.798
0.326
DD+PAPP-A+free β-hCG+NT
0.122
0.088
0.660
0.975
7.465
0.101
HDP ()
DD
0.360
0.245
0.755
0.640
2.096
0.384
PAPP-A
0.733
0.218
0.610
0.455
1.066
0.818
Free β-hCG
0.547
0.309
0.650
0.500
1.264
0.682
NT
0.595
0.325
0.634
0.449
1.134
0.803
DD+PAPP-A
0.633
0.018
0.695
0.932
1.550
0.050
DD+free β-hCG
0.633
0.018
0.695
0.932
1.550
0.050
PAPP-A+free β-hCG
0.720
0.177
0.626
0.519
1.143
0.633
DD+PAPP-A+free β-hCG
0.400
0.191
0.748
0.682
2.023
0.318
PAPP-A+free β-hCG+NT
0.679
0.170
0.651
0.553
1.222
0.530
DD+PAPP-A+free β-hCG+NT
0.458
0.145
0.740
0.710
1.867
0.268
DD: D-dimer; PAPP-A: pregnancy-associated plasma protein A; free β-hCG: free beta human chorionic gonadotropin; NT: nuchal translucency; MoM: multiple of the median; GH: gestational hypertension; PE: preeclampsia; SPE: severe preeclampsia; HDP: hypertensive disorders of pregnancy; AUC: area under curve; FNR: false negative rate; FPR: false positive rate; PPV: positive predictive value; NPV: negative predictive value; +LR: positive likelihood ratio; -LR: negative likelihood ratio.
