Optimal Biologic Drugs for the Treatment of Ankylosing Spondylitis: Results from a Network Meta-Analysis and Network Metaregression

Figure 1

Structure of network formed by interventions. The lines between treatment nodes indicate the direct comparisons made within randomized controlled trials. (a) Main network meta-analysis. (b) Subgroup analysis. Pla: placebo; DMARDs: disease-modifying antirheumatic drugs; IL6i: IL-6 inhibitor; IL17Ai: IL-17A inhibitor; IL17AFi: IL-17A/F inhibitor; IL23i: IL-23 inhibitor; JAKi: JAK inhibitor; TNFiFCP: TNF-α inhibitor FC fusion protein; TNFiFMA: TNF-α fully human monoclonal antibody; Sul: sulfasalazine; Toc: tocilizumab; Sec: secukinumab; Ixe: ixekizumab; Net: netakimab; Bim: bimekizumab; Ris: risankizumab; Ust: ustekinumab; Fil: filgotinib; Tof: tofacitinib; Upa: upadacitinib; Eta: etanercept; Inf: infliximab; Ada: adalimumab; Cer: certolizumab pegol; Gol: golimumab.

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