Research Article

Neutrophil Extracellular Traps Facilitate A549 Cell Invasion and Migration in a Macrophage-Maintained Inflammatory Microenvironment

Figure 6

The contribution of NETs in promoting A549 lung cancer cell migration and invasion. To detect the invasion and metastasis abilities of A549 lung cancer cells, Transwell and Matrigel assays were performed. A coculture system of THP-1 and A549 cells was constructed. NETs and NET inhibitors (anti-NE antibody and DNase) promoted the (a, c) migration and (b, d) invasion of A549 lung cancer cells. .
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